1-咪唑并[1,2-b]哒嗪-3-基乙酮合成路线 （共 2 条）
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=100°C; 18 h; Inert atmosphereSealed tube; 2: With hydrogenchloride in 1,4-dioxane; methanol
参考文献
MERCK SHARP andamp;; DOHME CORP.; ALTMAN, Michael, D.; BILODEAU, Mark, T.; LIM, Jongwon; NORTHRUP, Alan; STANTON, Matthew, G.; TAOKA, Brandon, M.
Patent: WO2010/83145 A1, 2010 ;
Location in patent: Page/Page column 56-57 ;
WO 2010/083145 A1
反应条件
hydrogen; triethylamine; palladium on activated charcoal T=20°C; P=760 Torr; 2 h;
参考文献
Byth, Kate F.; Cooper, Nicola; Culshaw, Janet D.; Heaton, David W.; Oakes, Sandra E.; Minshull, Claire A.; Norman, Richard A.; Pauptit, Richard A.; Tucker, Julie A.; Breed, Jason; Pannifer, Andrew; Rowsell, Sian; Stanway, Judith J.; Valentine, Anna L.; Thomas, Andrew P.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2249 - 2252
