3-溴-5-(三氟甲氧基)苯甲酸合成路线 （共 3 条）
反应条件
sulfuric acid; sodium nitrite in sodium hydroxide; ethanol; water
参考文献
US2003/55085 A1, ;
US 20030055085 A1
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=-70 - 25°C; 2: With sodium hydroxide; water in diethyl ether T=-70 - 25°C;
参考文献
MERCK and CO., INC.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.
Patent: WO2008/57209 A1, 2008 ;
Location in patent: Page/Page column 53-54 ;
WO 2008/057209 A1
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexanes
T=100°C; 2 h; Microwave irradiation;
2: With hydrogenchloride in water
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2009/78983 A1, 2009 ;
Location in patent: Page/Page column 101 ;
WO 2009/078983 A1
