3-溴-5-氰基苯甲酸甲酯合成路线 （共 7 条）
反应条件
lithium hydroxide hydrate; water in tetrahydrofuran T=20°C;
参考文献
WO2013/37705 A2, ;
Page/Page column 139 ;
WO 2013/037705 A2
反应条件
trichlorophosphate
T=100°C;
参考文献
FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David
Patent: WO2013/37705 A2, 2013 ;
Location in patent: Page/Page column 139 ;
WO 2013/037705 A2
反应条件
tetrakis (triphenylphosphine) palladium (0) in hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Wagenen, Bradford Van; Stormann, Thomas M.; Moe, Scott T.; Sheehan, Susan M.; McLeod, Donald A.; Smith, Daryl L.; Isaac, Methvin Benjamin; Slassi, Abdelmalik
Patent: US2003/55085 A1, 2003 ;
US 20030055085 A1
反应条件
1: lithium hydroxide hydrate; water / tetrahydrofuran / 20 °C
2: thionyl chloride / |Reflux
3: ammonia / tetrahydrofuran
4: trichlorophosphate / 100 °C
View Scheme
参考文献
FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David
Patent: WO2013/37705 A2, 2013 ;
WO 2013/037705 A2
反应条件
1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 20 °C
2.1: lithium hydroxide hydrate; water / tetrahydrofuran / 20 °C
3.1: thionyl chloride / |Reflux
4.1: ammonia / tetrahydrofuran
5.1: trichlorophosphate / 100 °C
View Scheme
参考文献
FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David
Patent: WO2013/37705 A2, 2013 ;
WO 2013/037705 A2
反应条件
1: thionyl chloride / |Reflux
2: ammonia / tetrahydrofuran
3: trichlorophosphate / 100 °C
View Scheme
参考文献
FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David
Patent: WO2013/37705 A2, 2013 ;
WO 2013/037705 A2
反应条件
1: ammonia / tetrahydrofuran
2: trichlorophosphate / 100 °C
View Scheme
参考文献
FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David
Patent: WO2013/37705 A2, 2013 ;
WO 2013/037705 A2
