2-溴甲基-1-氟-4-硝基苯合成路线 （共 5 条）
反应条件
in ethanol; water T=22°C; 4 h;
参考文献
Bunce, Richard A.; Nago, Takahiro; Sonobe, Nathan; Slaughter, LeGrande M.
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 2 p. 551 - 557
反应条件
phosphorus tribromide in chloroform
T=37 - 60°C;
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; Krüger, Joachim; Grossbach, Danja; Paulsen, Holger; Kroh, Walter
Patent: US2013/116443 A1, 2013 ;
Location in patent: Paragraph 0117; 0118 ;
反应条件
bromine
2.5 h; HeatingIrradiation;
参考文献
O'Neill, Paul M.; Harrison, Anthony C.; Storr, Richard C.; Hawley, Shaun R.; Ward, Stephen A.; Park, B. Kevin
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1362 - 1370
反应条件
N-bromosuccinmide in tetrachloromethane; dichloromethane; cyclohexane; ethyl acetate
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2010/261759 A1, 2010 ;
US 20100261759 A1
参考文献
Sveinbjornsson; VanderWerf
Journal of the American Chemical Society, 1951 , vol. 73, p. 1378
