1: in tetrahydrofuran; methanol
T=-10 - -5°C; 2 h;
2: With sodium tris(acetoxy)borohydride in tetrahydrofuran; methanol
T=-5°C; 1 h;
3: With hydrogenchloride; potassium hydroxide; trifluoroacetic acid
more than 3 stages;
参考文献
ASTRAZENECA UK LIMITED
Patent: WO2005/116023 A1, 2005 ;
Location in patent: Page/Page column 45-46 ;
WO 2005/116023 A1