2-氨基-4-三氟甲基苯酚合成路线 （共 15 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=40°C; P=2068.65 Torr;
参考文献
Merial Limited; Meng, Charles Q.; Long, Alan; Huber, Scot; Gurrala, Srinivas Reddy; Wilkinson, Douglas Edward; Pacofsky, Gregory
Patent: US2014/142114 A1, 2014 ;
Location in patent: Paragraph 0859; 0860 ;
参考文献
SmithKline Beecham Corporation
Patent: US6262113 B1, 2001 ;
US 6262113 B1
参考文献
SmithKline Beecham Corporation
Patent: US5886044 A1, 1999 ;
US 5886044 A
反应条件
1: acetic acid; nitric acid / 1 h / 20 - 40 °C 2: acetic acid; iron / water / 0.75 h / 135 °C View Scheme
参考文献
Kozic, Jan; Novotna, Eva; Volkova, Marie; Stolarikova, Jirina; Trejtnar, Frantisek; Wsol, Vladimir; Vinsova, Jarmila
European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 108 - 119
反应条件
1: NaOH; DMSO 2: iron; aqueous methanol. HCl View Scheme
参考文献
Kimura et al.
Kogyo Kagaku Zasshi, 1959 , vol. 62, p. 227,229
Chem.Abstr., 1962 , vol. 57, p. 989
反应条件
1: aqueous H2SO4; NaNO2 / anschliessendes Erhitzen mit CuSO4 2: Raney nickel; ethanol / Hydrogenation View Scheme
参考文献
Pettit; Tatlow
Journal of the Chemical Society, 1954 , p. 3852
反应条件
sulfuric acid; copper(l) chloride; sodium nitrite
参考文献
Zhou, Xinming; He, Yantao; Wang, Miao; Ding, Yixiang
Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 3 p. 651 - 659
反应条件
sodium acetate in ethyl acetate 0.25 h; Heating;
参考文献
Sam,J. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 408 - 410
反应条件
2: PbO2 3: aq. HCl / 18 h / Heating View Scheme
参考文献
Sam; Valentine; Richmond
Journal of pharmaceutical sciences, 1968 , vol. 57, # 10 p. 1763 - 1768
参考文献
Sam; Valentine; Richmond
Journal of pharmaceutical sciences, 1968 , vol. 57, # 10 p. 1763 - 1768
