2-甲基-3-羟基-4-羟基甲基-5-羧基吡啶内酯合成路线 （共 15 条）
反应条件
hydrogen; 5-palladium/activated carbon in ethyl acetate
参考文献
AMBRILIA BIOPHARMA INC.
Patent: WO2009/146555 A1, 2009 ;
Location in patent: Page/Page column 87 ;
反应条件
sulfuric acid; sodium nitrite
anschliessend Erwaermen;
参考文献
Harris et al.
Journal of the American Chemical Society, 1939 , vol. 61, p. 1242
反应条件
Me3SiH(OEt)2; tetrabutyl ammonium fluoride in tetrahydrofuran
T=22°C; 24 h;
参考文献
Dumond, Yves Rene; Gum, Andrew G.
Molecules, 2003 , vol. 8, # 12 p. 873 - 881
反应条件
1: concentrated H2SO4; HNO3
2: POCl3; PCl5
3: palladium/BaCO3; ethyl acetate; ethanol / 60 °C / Hydrogenation
4: NaNO2; aqueous H2SO4 / anschliessend Erwaermen
View Scheme
参考文献
Harris et al.
Journal of the American Chemical Society, 1939 , vol. 61, p. 1242
反应条件
1: POCl3; PCl5
2: palladium/BaCO3; ethyl acetate; ethanol / 60 °C / Hydrogenation
3: NaNO2; aqueous H2SO4 / anschliessend Erwaermen
View Scheme
参考文献
Harris et al.
Journal of the American Chemical Society, 1939 , vol. 61, p. 1242
反应条件
1: palladium/BaCO3; ethyl acetate; ethanol / 60 °C / Hydrogenation
2: NaNO2; aqueous H2SO4 / anschliessend Erwaermen
View Scheme
参考文献
Harris et al.
Journal of the American Chemical Society, 1939 , vol. 61, p. 1242
反应条件
1: concentrated aqueous HCl
2: concentrated H2SO4; HNO3
3: POCl3; PCl5
4: palladium/BaCO3; ethyl acetate; ethanol / 60 °C / Hydrogenation
5: NaNO2; aqueous H2SO4 / anschliessend Erwaermen
View Scheme
参考文献
Harris et al.
Journal of the American Chemical Society, 1939 , vol. 61, p. 1242
反应条件
1: NaOCl, aq. KOH
2: (i) aq. KNO2, aq. H2SO4, (ii) /BRN= 4652394/
3: aq. HCl
View Scheme
参考文献
Argoudelis,C.J.; Kummerow,F.A.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2663 - 2665
参考文献
Argoudelis,C.J.; Kummerow,F.A.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2663 - 2665
反应条件
1: (i) aq. KNO2, aq. H2SO4, (ii) /BRN= 4652394/
2: aq. HCl
View Scheme
参考文献
Argoudelis,C.J.; Kummerow,F.A.
Journal of Organic Chemistry, 1964 , vol. 29, p. 2663 - 2665
