4,6-二氯-5-(间溴苯胺基)嘧啶合成路线 （共 3 条）
反应条件
trichlorophosphate in N,N-dimethyl-formamide
15 h; Heating;
参考文献
Gomtsyan, Arthur; Didomenico, Stanley; Lee, Chih-Hung; Matulenko, Mark A.; Kim, Ki; Kowaluk, Elizabeth A.; Wismer, Carol T.; Mikusa, Joe; Yu, Haixia; Kohlhaas, Kathy; Jarvis, Michael F.; Bhagwatt, Shripad S.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3639 - 3648
反应条件
1.1: 77 percent / 15 h / 40 - 50 °C
2.1: sodium ethoxide / ethanol / 0 °C
2.2: 63 percent / ethanol / 20 °C
3.1: 38 percent / POCl3 / dimethylformamide / 15 h / Heating
View Scheme
参考文献
Gomtsyan, Arthur; Didomenico, Stanley; Lee, Chih-Hung; Matulenko, Mark A.; Kim, Ki; Kowaluk, Elizabeth A.; Wismer, Carol T.; Mikusa, Joe; Yu, Haixia; Kohlhaas, Kathy; Jarvis, Michael F.; Bhagwatt, Shripad S.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3639 - 3648
反应条件
1.1: sodium ethoxide / ethanol / 0 °C
1.2: 63 percent / ethanol / 20 °C
2.1: 38 percent / POCl3 / dimethylformamide / 15 h / Heating
View Scheme
参考文献
Gomtsyan, Arthur; Didomenico, Stanley; Lee, Chih-Hung; Matulenko, Mark A.; Kim, Ki; Kowaluk, Elizabeth A.; Wismer, Carol T.; Mikusa, Joe; Yu, Haixia; Kohlhaas, Kathy; Jarvis, Michael F.; Bhagwatt, Shripad S.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3639 - 3648
