4,6-二碘-5-氨基嘧啶合成路线 （共 6 条）
反应条件
hydrogen iodide; sodium iodide in acetone
T=20°C;
参考文献
Latli, Bachir; Jones, Paul-James; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 1 p. 54 - 58
反应条件
1: 4,6-diiodo-pyrimidin-5-ylamine With sodium hydride in tetrahydrofuran
T=0 - 20°C;
2: benzyl bromide With tetra-(n-butyl)ammonium iodide in tetrahydrofuran
T=20°C;
参考文献
Gomtsyan, Arthur; Didomenico, Stanley; Lee, Chih-Hung; Matulenko, Mark A.; Kim, Ki; Kowaluk, Elizabeth A.; Wismer, Carol T.; Mikusa, Joe; Yu, Haixia; Kohlhaas, Kathy; Jarvis, Michael F.; Bhagwatt, Shripad S.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 17 p. 3639 - 3648
反应条件
1: 4,6-diiodo-pyrimidin-5-ylamine With sodium hydride in tetrahydrofuran
T=0 - 20°C;
2: methyl iodide in tetrahydrofuran
T=20°C;
参考文献
Ibrahim, Nada; Legraverend, Michel
Journal of Organic Chemistry, 2009 , vol. 74, # 1 p. 463 - 465
反应条件
1: 4,6-diiodo-pyrimidin-5-ylamine With sodium hydride in tetrahydrofuran; mineral oil
T=0°C; 0.5 h;
2: methanesulphonic acid methyl ester in tetrahydrofuran; mineral oil
T=0 - 20°C; 4 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one
T=110°C; 1 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/4749 A1, 2007 ;
Location in patent: Page/Page column 141-142 ;
WO 2007/004749 A1
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran
T=-30 - -20°C; 0.833333 h;
2: With ammonium chloride in tetrahydrofuran; water
cooling; Further stages.;
参考文献
Latli, Bachir; Jones, Paul-James; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 1 p. 54 - 58
