1H-吡咯并[2,3-d]嘧啶-5-甲腈合成路线 （共 4 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
3 h;
参考文献
Billedeau, Roland Joseph; Kondru, Rama K.; Lopez-Tapia, Francisco Javier; Lou, Yan; Owens, Timothy D.; Qian, Yimin; So, Sung-Sau; Thakkar, Kshitij C.; Wanner, Jutta
Patent: US2012/295885 A1, 2012 ;
Location in patent: Page/Page column 61 ;
反应条件
palladium 10 on activated carbon; hydrogen; sodium hydrogencarbonate in ethanol
T=70°C; P=75007.5 Torr; 24 h; Autoclave;
参考文献
Wilding, Birgit; Winkler, Margit; Petschacher, Barbara; Kratzer, Regina; Egger, Sigrid; Steinkellner, Georg; Lyskowski, Andrzej; Nidetzky, Bernd; Gruber, Karl; Klempier, Norbert
Chemistry - A European Journal, 2013 , vol. 19, # 22 p. 7007 - 7012
反应条件
1: N-iodo-succinimide / acetonitrile / 3 h
2: triethylamine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 3 h
3: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h
View Scheme
参考文献
Billedeau, Roland Joseph; Kondru, Rama K.; Lopez-Tapia, Francisco Javier; Lou, Yan; Owens, Timothy D.; Qian, Yimin; So, Sung-Sau; Thakkar, Kshitij C.; Wanner, Jutta
Patent: US2012/295885 A1, 2012 ;
反应条件
1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h
View Scheme
参考文献
Billedeau, Roland Joseph; Kondru, Rama K.; Lopez-Tapia, Francisco Javier; Lou, Yan; Owens, Timothy D.; Qian, Yimin; So, Sung-Sau; Thakkar, Kshitij C.; Wanner, Jutta
Patent: US2012/295885 A1, 2012 ;
