1: 4-trifluoromethylaniline With hydrogenchloride in water
0.5 h;
2: With sodium nitrite in water
T=0°C;
3: maleic imide With sodium acetate; copper dichloride in water; acetone
T=0°C; pH=3 - 3.5;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/136223 A1, 2006 ;
Location in patent: Page/Page column 30 ;
WO 2006/136223 A1
Hallas, Geoffrey; Marsden, Richard; Hepworth, John D.; Mason, Donald
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , # 1 p. 149 - 154