1: With (2R,3S,3aS,4aR,6R,8aS)-2-isopropyl-6,9,9-trimethyl-3-phenyldecahydro-4aH-pyrrolo[2,1-b][1,3]benzoxazin-3-ol in hexane; toluene T=20°C; Inert atmosphere; 2: With ammonium chloride in hexane; water; toluene optical yield given as percent eeenantioselective reaction;
1: triethylaluminum With 1,4-diaza-bicyclo[2.2.2]octane in tetrahydrofuran 2: 4-trifluoromethyl-benzaldehyde With [(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=5°C; 1 h; Title compound not separated from byproducts;
参考文献
Raluy, Eva; Dieguez, Montserrat; Pamies, Oscar
Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4495 - 4497
4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide in hexane T=0°C; 24 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Hirose, Takuji; Sugawara, Kazuyuki; Kodama, Koichi
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5413 - 5428
