3,5-二氟苯甲酸合成路线

参考文献

Thornton, Timothy J.; Jarman, Michael
Synthesis, 1990 , p. 295 - 299

参考文献

ASTEX THERAPEUTICS LIMITED
Patent: WO2006/40569 A1, 2006 ;
Location in patent: Page/Page column 82-83 ;
WO 2006/040569 A1

455-40-33,5-二氟苯甲酸

331765-71-03,5-二氟-2-硝基苯甲酸

参考文献

PFIZER INC.; BAILEY, Simon; BURKE, Benjamin, Joseph; COLLINS, Michael, Raymond; CUI, Jingrong, Jean; DEAL, Judith, Gail; HOFFMAN, Robert, Louis; HUANG, Qinhua; JOHNSON, Ted, William; KANIA, Robert, Steven; KATH, John, Charles; LE, Phuong, Thi, Quy; MCTIGUE, Michele, Ann; PALMER, Cynthia, Louise; RICHARDSON, Paul, Francis; SACH, Neal, William
Patent: WO2013/132376 A1, 2013 ;
Location in patent: Page/Page column 234 ;

455-40-33,5-二氟苯甲酸

132980-99-53,5-二氟苯甲酰胺

参考文献

Weikert; Bingham Jr.; Emanuel; Fraser-Smith; Loughhead; Nelson; Poulton
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1630 - 1633

455-40-33,5-二氟苯甲酸

126674-78-02-氨基-3,5-二氟苯甲酸

参考文献

PFIZER INC.; BAILEY, Simon; BURKE, Benjamin, Joseph; COLLINS, Michael, Raymond; CUI, Jingrong, Jean; DEAL, Judith, Gail; HOFFMAN, Robert, Louis; HUANG, Qinhua; JOHNSON, Ted, William; KANIA, Robert, Steven; KATH, John, Charles; LE, Phuong, Thi, Quy; MCTIGUE, Michele, Ann; PALMER, Cynthia, Louise; RICHARDSON, Paul, Francis; SACH, Neal, William
Patent: WO2013/132376 A1, 2013 ;

455-40-33,5-二氟苯甲酸

129714-97-23.5-二氟苯甲酰氯

参考文献

GLAXO GROUP LIMITED; HONG, Xuan; HUGHES, Terry, Vincent; MILLER, Nathan, A.; MISKOWSKI, Tamara, Ann; SEHON, Clark, A.
Patent: WO2010/80873 A1, 2010 ;
Location in patent: Page/Page column 44 ;
WO 2010/080873 A1

455-40-33,5-二氟苯甲酸+

124-41-4甲醇钠

176548-72-43-氟-5-甲氧基苯甲酸

参考文献

ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
Location in patent: Page/Page column 116; 117 ;
WO 2011/156518 A2

455-40-33,5-二氟苯甲酸

244022-63-73,5-二氟苄肼

参考文献

Hoffmann-La Roche Inc.
Patent: US6265426 B1, 2001 ;
US 6265426 B1

455-40-33,5-二氟苯甲酸

1214346-07-2

参考文献

ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
WO 2011/156518 A2

455-40-33,5-二氟苯甲酸

1239964-17-03,5-二氟-4-(羟基甲基)苯甲酸叔丁酯

参考文献

EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
WO 2010/093845 A1