1: 3,4-difluoro-benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran
0.5 h; Heating;
2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran
T=20°C; Further stages.;
参考文献
Jae; Winn; Von Geldern; Sorensen; Chiou; Nguyen; Marsh; Opgenorth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3978 - 3984