hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=30°C; P=2327.2 Torr; 18 h;
参考文献
Boden, P. R.; Eden, J. M.; Higginbottom, M.; Hill, D. R.; Horwell, D. C.; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 1 p. 47 - 61
1: hydrogen; trifluoroacetic acid / palladium 10 on activated carbon / methanol / 20 °C / 3677.86 Torr
2: ethanol / 18 h / 20 °C
3: potassium carbonate / acetone / 2 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, Lorin A., III.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2012/103297 A1, 2012 ;
