4-羟基甲基-2-甲基-1H-咪唑合成路线 （共 6 条）
反应条件
1: With cupric(II) carbonate; copper (II) hydroxide; ammonium hydroxide; air in water 2.5 h; Heating; 2: With ethanethioamide in water T=50°C; 2 h;
参考文献
Handy, Scott T.; Okello, Maurice
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1915 - 1918
参考文献
American Cyanamid Company
Patent: US4168964 A1, 1979 ;
参考文献
University of Pittsburgh
Patent: US2002/193596 A1, 2002 ;
反应条件
sodium tetrahydroborate in ethanol 3 h;
参考文献
Madsen, Christian; Jensen, Anders A.; Liljefors, Tommy; Kristiansen, Uffe; Nielsen, Birgitte; Hansen, Camilla P.; Larsen, Mogens; Ebert, Bjarke; Bang-Andersen, Benny; Krogsgaard-Larsen, Povl; Frolund, Bente
Journal of Medicinal Chemistry, 2007 , vol. 50, # 17 p. 4147 - 4161
反应条件
copper carbonate hydroxide; ammonium hydroxide
参考文献
Ono; Hirohata
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1956 , vol. 304, p. 77,79
反应条件
1: SOCl2 2: dimethylsulfoxide 3: HCl; AcOH View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3721 - 3738
