反应条件
1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane; diethyl ether 2.1: N-ethyl-N,N-diisopropylamine; 4-(N,N-dimethlyamino)pyridine / 1,4-dioxane / 96 h / 120 °C 2.2: 760.05 Torr / |Sealed tube View Scheme
参考文献
Madrigal Pharmaceuticals, Inc.; BOLIN, David, R.; CHEUNG, Adrian, Wai-hing; HAMILTON, Matthew, Michael; MARCOPULOUS, Nicholas; McDERMOTT, Lee, Apostle; QIAN, Yimin
Patent: EP2350311 B1, 2013 ;