1: acetoacetic acid methyl ester With sodium hydride in tetrahydrofuran
T=0°C; 0.166667 h;
2: n-butyllithium in tetrahydrofuran; cyclohexane
T=0°C; 0.166667 h;
3: 3-fluoro-1-bromomethylbenzene With hydrogenchloride
more than 3 stages;
参考文献
Chen, Shoujun; Sun, Lijun; McCleary, Joel
Patent: US2003/236302 A1, 2003 ;
Location in patent: Page 11 ;