1,3,3,5,5-五甲基环己胺甲烷磺酸盐合成路线 （共 4 条）
反应条件
in ethyl acetate
T=0 - 5°C; 1 h;
参考文献
MERZ PHARMA GMBH and CO. KGAA; KOLLER, Herbert; PYERIN, Michael; SBROGIO, Federico
Patent: WO2011/538 A1, 2011 ;
Location in patent: Page/Page column 40 ;
反应条件
1.1: copper(l) iodide; lithium chloride / tetrahydrofuran / 1 h / 5 - 15 °C
2.1: tetrahydrofuran / 5 - 15 °C
3.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C
4.1: hydrogenchloride; thiourea / water / 6 h / Reflux
4.2: pH 7
5.1: ethyl acetate / 1 h / 0 - 5 °C
View Scheme
参考文献
MERZ PHARMA GMBH and CO. KGAA; KOLLER, Herbert; PYERIN, Michael; SBROGIO, Federico
Patent: WO2011/538 A1, 2011 ;
反应条件
1.1: tetrahydrofuran / 5 - 15 °C
2.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C
3.1: hydrogenchloride; thiourea / water / 6 h / Reflux
3.2: pH 7
4.1: ethyl acetate / 1 h / 0 - 5 °C
View Scheme
参考文献
MERZ PHARMA GMBH and CO. KGAA; KOLLER, Herbert; PYERIN, Michael; SBROGIO, Federico
Patent: WO2011/538 A1, 2011 ;
反应条件
1.1: hydrogenchloride; thiourea / water / 6 h / Reflux
1.2: pH 7
2.1: ethyl acetate / 1 h / 0 - 5 °C
View Scheme
参考文献
MERZ PHARMA GMBH and CO. KGAA; KOLLER, Herbert; PYERIN, Michael; SBROGIO, Federico
Patent: WO2011/538 A1, 2011 ;
