4-氨基-3-(三氟甲氧基)苯甲酸甲酯合成路线 （共 5 条）
反应条件
1.1: water; sodium nitrite; hydrogenchloride / acetonitrile / 0.67 h / 0 °C 1.2: 0.25 h / 0 °C / |Inert atmosphere 2.1: sodium hydroxide; water / methanol / 1.5 h / 20 °C View Scheme
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine
T=100°C; P=15201 Torr; 36 h;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
反应条件
1: With thionyl chloride
Heating / reflux;
2: With sodium hydrogencarbonate in water
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2017263 A1, 2009 ;
Location in patent: Page/Page column 213 ;
EP 2017263 A1
反应条件
hydrogenchloride in 1,4-dioxane; methanol
参考文献
THERAVANCE, INC.
Patent: US2012/114600 A1, 2012 ;
反应条件
in tetrahydrofuran; methanol; hexane; ethyl acetate
参考文献
Keegan, Kathleen S.; Kesicki, Edward A.; Gaudino, John Joseph; Cook, Adam Wade; Cowen, Scott Douglas; Burgess, Laurence Edward
Patent: US2003/69284 A1, 2003 ;
US 20030069284 A1
