9beta,11beta-环氧-6alpha-氟-17,21-二羟基-16alpha-甲基孕甾-1,4-二烯-3,20-二酮 21-乙酸酯合成路线 （共 5 条）
反应条件
1: potassium carbonate; water / methanol / 10 h 2: hydrogenchloride / water / 5 h / -15 - -10 °C 3: isopropyl alcohol; trimethylsilyl iodide / acetonitrile / 0.25 h / 20 °C / Inert atmosphere View Scheme
参考文献
TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor
Patent: WO2012/11106 A1, 2012 ;
反应条件
water; potassium carbonate in methanol 10 h;
参考文献
TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor
Patent: WO2012/11106 A1, 2012 ;
Location in patent: Page/Page column 19-20 ;
反应条件
hydrogen fluoride in tetrahydrofuran; dichloromethane; ethyl acetate
参考文献
Syntex (U.S.A.) Inc.
Patent: US4207235 A1, 1980 ;
反应条件
1: potassium carbonate; water / methanol / 10 h 2: hydrogen fluoride / 5 h / -15 - -10 °C 3: trimethylsilyl iodide / acetonitrile / 2 h / -20 °C / Inert atmosphere View Scheme
反应条件
1: potassium carbonate; water / methanol / 10 h 2: hydrogen fluoride / 5 h / -15 - -10 °C View Scheme
参考文献
TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor
Patent: WO2012/11106 A1, 2012 ;
