2,2,5-三甲基环戊酮合成路线 （共 14 条）
反应条件
1.1.3-trimethyl-cyclopentanone-(2) whose optical behaviour not/no known is;
参考文献
Wallach; Kempe
Justus Liebigs Annalen der Chemie, 1903 , vol. 329, p. 100
Chem. Zentralbl., 1902 , vol. 73, # I p. 1294
反应条件
hydrogenchloride in methanol; water
pH=1; 1 h; Reflux;
参考文献
BIKAM PHARMACEUTICALS, INC.; QUACH, Tan; BERMAN, Judd; GARVEY, David, S.
Patent: WO2013/81642 A1, 2013 ;
Location in patent: Page/Page column 115 ;
反应条件
methyllithium in tetrahydrofuran
T=0°C; 3 h; Further byproducts given;
参考文献
Morita, Yasushi; Suzuki, Masaaki; Noyori, Ryoji
Journal of Organic Chemistry, 1989 , vol. 54, # 8 p. 1785 - 1787
反应条件
sodium tert-pentoxide in diethyl ether; benzene
参考文献
House,H.O.; Trost,B.M.
Journal of Organic Chemistry, 1965 , vol. 30, p. 2502 - 2512
反应条件
methyllithium in tetrahydrofuran
T=0°C; 3 h; var. temp., times, and reagent systems; other lithium enolates; Product distribution;
参考文献
Morita, Yasushi; Suzuki, Masaaki; Noyori, Ryoji
Journal of Organic Chemistry, 1989 , vol. 54, # 8 p. 1785 - 1787
反应条件
in methanol
1.5 h; HeatingpH 1; Yield given;
参考文献
Huguet, Joan; Karpf, Martin; Dreiding, Andre S.
Helvetica Chimica Acta, 1982 , vol. 65, # 8 p. 2413 - 2421
反应条件
sodium amide
Behandeln mit Methyljodid in Aether;
参考文献
Haller; Cornubert
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1914 , vol. 158, p. 304
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Quesnel, Yannick; Bidois-Sery, Laure; Poirier, Jean-Marie; Duhamel, Lucette
Synlett, 1998 , # 4 p. 413 - 415
反应条件
trockene Destillation des Calciumsalzes; α.α.α'-trimethyl-adipic acid from pulegone;
参考文献
Wallach; Kempe
Justus Liebigs Annalen der Chemie, 1903 , vol. 329, p. 100
Chem. Zentralbl., 1902 , vol. 73, # I p. 1294
反应条件
Behandeln mit Methyljodid;
参考文献
Haller; Cornubert
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1914 , vol. 158, p. 304
