1: With lithium hexamethyldisilazane in tetrahydrofuran; diethyl ether
Inert atmosphereCooling with ice;
2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether
Cooling with ice;
3: With sodium hydroxide in water
pH=14;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/20377 A1, 2011 ;
Location in patent: Page/Page column 11; 12 ;
US 20110020377 A1