4,5-二氢-2-(2-噻吩)-1H-咪唑合成路线 （共 16 条）
反应条件
1: 37 percent / 2percent Pd/C / diphenyl ether / 2 h / Heating 2: 85 percent / KOH / 1,2-dimethoxy-ethane / 0.5 h / 8 °C View Scheme
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 27, # 10 p. 1140 - 1144
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 27, # 10 p. 1414 - 1418
反应条件
[bis(acetoxy)iodo]benzene; potassium carbonate in dimethyl sulfoxide T=20°C; 24 h;
参考文献
Haneda, Satoshi; Okui, Ayaka; Ueba, Chigusa; Hayashi, Masahiko
Tetrahedron, 2007 , vol. 63, # 11 p. 2414 - 2417
反应条件
tetraphosphorus decasulfide
0.0416667 h; microwave irradiation;
参考文献
Moghadam, Majid; Mohammadpoor-Baltork, Iraj; Mirkhani, Valiollah; Tangestaninejad, Shahram; Abdollahi-Alibeik, Mohammad; Yousefi, Behrooz H.; Kargar, Hadi
Monatshefte fur Chemie, 2007 , vol. 138, # 6 p. 579 - 583
反应条件
iodine; potassium carbonate in tert-butyl alcohol
T=70°C; 3 h;
参考文献
Ishihara, Midori; Togo, Hideo
Tetrahedron, 2007 , vol. 63, # 6 p. 1474 - 1480
反应条件
1: thiophene-2-methanol With iodine; potassium carbonate in tert-butyl alcohol
T=70°C; 8 h;
2: ethylenediamine in tert-butyl alcohol
T=70°C; 2 h;
参考文献
Ishihara, Midori; Togo, Hideo
Tetrahedron, 2007 , vol. 63, # 6 p. 1474 - 1480
反应条件
toluene-4-sulfonic acid in water; ethylene glycol
8 h; Heating;
参考文献
Stoyanov, V. M.; El'chaninov, M. M.; Pozharskii, A. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 10 p. 1140 - 1144
Khimiya Geterotsiklicheskikh Soedinenii, 1991 , vol. 27, # 10 p. 1414 - 1418
反应条件
1,3-bis-(diphenylphosphino)propane; caesium carbonate; palladium dichloride in toluene
16 h; Inert atmosphereReflux;
参考文献
Geden, Joanna V.; Pancholi, Alpa K.; Shipman, Michael
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4158 - 4164
反应条件
in acetonitrile
10 h; Heating;
参考文献
Chadwick; Ennis
Tetrahedron, 1991 , vol. 47, # 47 p. 9901 - 9914
反应条件
1: CH2Cl2 / 16 h / 20 °C
2: SOCl2 / toluene / 16 h / 20 °C
3: 87 percent / 10 h / Heating
View Scheme
参考文献
Chadwick; Ennis
Tetrahedron, 1991 , vol. 47, # 47 p. 9901 - 9914
反应条件
1: SOCl2 / 2 h / Heating
2: CH2Cl2 / 16 h / 20 °C
3: SOCl2 / toluene / 16 h / 20 °C
4: 87 percent / 10 h / Heating
View Scheme
参考文献
Chadwick; Ennis
Tetrahedron, 1991 , vol. 47, # 47 p. 9901 - 9914
