间氟苯乙酰氯间氟苯乙酰氯合成路线 （共 12 条）
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
1: (COCl)2; DMF / CH2Cl2 2: diethyl ether / 0 °C 3: aq. Ag2O / dioxane 4: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
1: aq. Ag2O / dioxane 2: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
1: diethyl ether / 0 °C 2: aq. Ag2O / dioxane 3: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
1: (hydrolysis) 2: SOCl2 View Scheme
参考文献
Adcock,W. et al.
Australian Journal of Chemistry, 1970 , vol. 23, p. 1921 - 1937
反应条件
1: NBS 3: (hydrolysis) 4: SOCl2 View Scheme
参考文献
Adcock,W. et al.
Australian Journal of Chemistry, 1970 , vol. 23, p. 1921 - 1937
反应条件
2: (hydrolysis) 3: SOCl2 View Scheme
参考文献
Adcock,W. et al.
Australian Journal of Chemistry, 1970 , vol. 23, p. 1921 - 1937
反应条件
aluminium trichloride in dichloromethane T=0°C;
参考文献
Pendergast; Johnson; Dickerson; Dev; Duch; Ferone; Hall; Humphreys; Kelly; Wilson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2279 - 2291
反应条件
aluminium trichloride in dichloromethane T=0°C;
参考文献
Pendergast; Johnson; Dickerson; Dev; Duch; Ferone; Hall; Humphreys; Kelly; Wilson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2279 - 2291
参考文献
Adcock,W. et al.
Australian Journal of Chemistry, 1970 , vol. 23, p. 1921 - 1937
