2-氟-1-碘-4-甲氧基苯合成路线 （共 3 条）
反应条件
toluene-4-sulfonic acid; potassium iodide; sodium nitrite in water; acetonitrile
T=12 - 20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ELLSWORTH, Bruce, A.; JURICA, Elizabeth, A.; SHI, Jun; EWING, William, R.; YE, Xiang-Yang; WU, Ximao; ZHU, Yeheng; SUN, Chongqing
Patent: WO2014/78609 A1, 2014 ;
Location in patent: Paragraph 00447 ;
反应条件
potassium tert-butylate in 1,4-dioxane
T=45°C; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Ouellet, Stephane G.; Bernardi, Anna; Angelaud, Remy; O'Shea, Paul D.
Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3776 - 3779
反应条件
1: iron-powder; aqueous acetic acid
2: Diazotization
View Scheme
参考文献
Hodgson; Nixon
Journal of the Chemical Society, 1931 , p. 981
