1-甲基-4-丙炔-2-哌嗪合成路线 （共 5 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=0 - 20°C; 24 h; 2: With sodium hydroxide; water in tetrahydrofuran; diethyl ether T=0°C; 0.333333 h;
参考文献
Pfizer Inc.
Patent: US2004/192698 A1, 2004 ;
Location in patent: Page/Page column 13 ;
反应条件
potassium carbonate in dimethyl sulfoxide; toluene
T=5 - 80°C; 13 h;
参考文献
Player, Mark R.; Parsons, William H.; Huang, Hui; Hutta, Daniel A.; Hu, Huaping; Rinker, James
Patent: US2008/114007 A1, 2008 ;
Location in patent: Page/Page column 104 ;
反应条件
potassium carbonate in acetonitrile
72 h;
参考文献
Pfizer Inc.
Patent: US2004/192698 A1, 2004 ;
Location in patent: Page/Page column 13 ;
反应条件
sodium amide
Yield given;
参考文献
Mayrargue, Joeelle; Vayssiere, Michel; Miocque, Marcel
Heterocycles, 1985 , vol. 23, # 9 p. 2173 - 2175
反应条件
2: NaNH2
View Scheme
参考文献
Mayrargue, Joeelle; Vayssiere, Michel; Miocque, Marcel
Heterocycles, 1985 , vol. 23, # 9 p. 2173 - 2175
