3-(Boc-氨基)-3-环己基丙酸合成路线 (共 1 条)
反应条件
1: (R)-N-Boc-cyclohexyl-glycine With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran
T=0°C; 1 h;
2: diazomethane in tetrahydrofuran; diethyl ether
T=0 - 20°C;
3: With hydrogenchloride; sodium hydroxide; silver trifluoroacetate; triethylamine
more than 3 stages;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2006/17836 A2, 2006 ;
Location in patent: Page/Page column 306-307 ;