1: 98 percent / DMAP; Et3N / CH2Cl2 / 0.5 h / 20 °C 2: 51 percent / NBS; dibenzoyl peroxide / CCl4 / 3.83 h / 85 °C / Irradiation 3: 73 percent / 2,6-lutidine / dimethylformamide / 5.5 h / 120 °C 4: 80 percent / aq. NaOH / tetrahydrofuran / 1 h / 20 °C 5: 94 percent / Et3N / CH2Cl2 / 0.92 h 6: 77 percent / CH2Cl2 / 2.5 h / 20 °C 7: 0.142 g / TFA / CH2Cl2 / 0.92 h / 20 °C 8: PyBOP; diisopropylethylamine / dimethylformamide / 3 h View Scheme

1: 98 percent / DMAP; Et3N / CH2Cl2 / 0.5 h / 20 °C 2: 51 percent / NBS; dibenzoyl peroxide / CCl4 / 3.83 h / 85 °C / Irradiation 3: 73 percent / 2,6-lutidine / dimethylformamide / 5.5 h / 120 °C View Scheme

4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; 0.5 h;

1: 98 percent / DMAP; Et3N / CH2Cl2 / 0.5 h / 20 °C 2: 51 percent / NBS; dibenzoyl peroxide / CCl4 / 3.83 h / 85 °C / Irradiation View Scheme