1-(4-氟苯基)-2-硫脲合成路线 （共 13 条）
反应条件
1: With water; sodium hydroxide T=100°C; 1 h; 2: With hydrogenchloride in water
参考文献
COUNCIL OF SCIENTIFIC and INDUSTRIAL RESEARCH; SINGH, Supriya; ROY, Kuldeep Kumar; SHARMA, Sandeep Kumar; SRIVASTAVA, Ranjana; CHATURVEDI, Vinita; SAXENA, Anil Kumar
Patent: WO2012/164572 A1, 2012 ;
Location in patent: Page/Page column 35 ;
反应条件
hydrogenchloride in water 1 h;
参考文献
Dynamix Pharmaceuticals LTD.
Patent: US2012/316148 A1, 2012 ;
Location in patent: Page/Page column 154; 155 ;
US 20120316148 A1
反应条件
sodium hydroxide in water T=90°C; 20 h;
参考文献
Saxena, Anil K.; Pandey, Suresh K.; Seth; Singh; Dikshit; Carpy
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2025 - 2034
反应条件
1: acetone / 2 h / 20 °C 2: 43 percent / NaOH / H2O / 20 h / 90 °C View Scheme
参考文献
Dyson et al.
Journal of the Indian Chemical Society, 1931 , vol. 8, p. 147,163
参考文献
Saxena, Anil K.; Pandey, Suresh K.; Seth; Singh; Dikshit; Carpy
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2025 - 2034
反应条件
in water 4 h; Heating;
参考文献
Jacquot, Yves; Cleeren, Anny; Laios, Ioanna; Ma, Yan; Boulahdour, Athem; Bermont, Laurent; Refouvelet, Bernard; Adessi, Gerard; Leclercq, Guy; Xicluna, Alain
Biological and Pharmaceutical Bulletin, 2002 , vol. 25, # 3 p. 335 - 341
参考文献
Chen, Bor-Cherng; Shiu, Shi; Yang, Ding-Yah
Journal of the Chinese Chemical Society, 1998 , vol. 45, # 4 p. 549 - 553
反应条件
pyridine; hydrogen sulfide; triethylamine T=20°C; 72 h;
参考文献
Rist, ystein; Grimstrup, Marie; Receveur, Jean-Marie; Frimurer, Thomas M.; Ulven, Trond; Kostenis, Evi; Hoegberg, Thomas
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 1177 - 1180
反应条件
bromine in chloroform 2 h;
参考文献
Jacquot, Yves; Cleeren, Anny; Laios, Ioanna; Ma, Yan; Boulahdour, Athem; Bermont, Laurent; Refouvelet, Bernard; Adessi, Gerard; Leclercq, Guy; Xicluna, Alain
Biological and Pharmaceutical Bulletin, 2002 , vol. 25, # 3 p. 335 - 341
反应条件
1: bromine / CHCl3 / 4 h / Heating 2: 55 percent / KOH / H2O / Heating View Scheme
参考文献
Jacquot, Yves; Cleeren, Anny; Laios, Ioanna; Ma, Yan; Boulahdour, Athem; Bermont, Laurent; Refouvelet, Bernard; Adessi, Gerard; Leclercq, Guy; Xicluna, Alain
Biological and Pharmaceutical Bulletin, 2002 , vol. 25, # 3 p. 335 - 341
