2-(4-氟苯)-N-甲基乙胺合成路线 （共 7 条）
反应条件
hydrogen; 5-palladium/activated carbon in methanol
T=50°C;
参考文献
Eisai Co., Ltd.
Patent: US2005/227959 A1, 2005 ;
Location in patent: Page/Page column 34 ;
反应条件
1: benzene; PBr3 / 100 °C
2: butanol-(1)
View Scheme
参考文献
Suter; Weston
Journal of the American Chemical Society, 1941 , vol. 63, p. 602,603
反应条件
1: diethyl ether; benzene / <10
2: benzene; PBr3 / 100 °C
3: butanol-(1)
View Scheme
参考文献
Suter; Weston
Journal of the American Chemical Society, 1941 , vol. 63, p. 602,603
参考文献
Suter; Weston
Journal of the American Chemical Society, 1941 , vol. 63, p. 602,603
反应条件
1: toluene; water / 0.5 h / 0 - 22 °C / |Inert atmosphere
2: borane-THF / tetrahydrofuran / 4 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Nani, Roger R.; Reisman, Sarah E.
Journal of the American Chemical Society, 2013 , vol. 135, # 19 p. 7304 - 7311
反应条件
1: N,N-dimethyl-formamide; thionyl chloride / toluene / 0.5 h / 40 °C / |Inert atmosphere
2: toluene; water / 0.5 h / 0 - 22 °C / |Inert atmosphere
3: borane-THF / tetrahydrofuran / 4 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Nani, Roger R.; Reisman, Sarah E.
Journal of the American Chemical Society, 2013 , vol. 135, # 19 p. 7304 - 7311
参考文献
Neustadt, Bernard R.; Liu, Hong; Hao, Jinsong; Greenlee, William J.; Stamford, Andrew W.; Foster, Carolyn; Arik, Leyla; Lachowicz, Jean; Zhang, Hongtao; Bertorelli, Rosalia; Fredduzzi, Silva; Varty, Geoffrey; Cohen-Williams, Mary; Ng, Kwokei
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 967 - 971
