反应条件
1: 1.) n-butyllithium, 2.) tetrakis(triphenylphosphine)palladium(0) / 1.) ether, THF, hexane, 0 deg C, 1.5 h, 2.) ether, hexane, THF, RT, overnight 2: 95 percent / N-iodosuccinimide, acetic acid / CHCl3 / 1 h / Ambient temperature 3: 18 percent / triphenylphosphine, bis(acetonitrile)palladium(II) chloride, copper(I) iodide, diethylamine / dimethylformamide / 22 h / Ambient temperature View Scheme
参考文献
Brooks; Stewart; Basha; Bhatia; Ratajczyk; Martin; Craig; Kolasa; Bouska; Lanni; Harris; Malo; Carter; Bell
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4768 - 4775