二甲基吡啶-3,5-二羧酸合成路线 （共 20 条）
反应条件
1: LiAlH4 / diethyl ether / 15 h 2: 47 percent / SOCl2 / 18 h / Heating View Scheme
参考文献
Lagunas, Maria-Cristina; Gossage, Robert A.; Smeets, Wilberth J. J.; Spek, Anthony L.; Van Koten, Gerard
European Journal of Inorganic Chemistry, 1998 , # 2 p. 163 - 168
反应条件
potassium hydroxide in methanol T=20°C; 12 h;
参考文献
Broadus, Katherine M.; Kass, Steven R.
Journal of the American Chemical Society, 2000 , vol. 122, # 37 p. 9014 - 9018
反应条件
lithium aluminium reduction;
参考文献
Momenteau, Michel; Mispelter, Joel; Loock, Bernard; Lhoste, Jean-Marc
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 61 - 70
反应条件
water; potassium hydroxide in methanol T=20°C; 3 h;
参考文献
Astellas Pharma Inc.
Patent: WO2006/123725 A1, 2006 ;
Location in patent: Page/Page column 85 ;
反应条件
hydrazine hydrate in ethanol Heating;
参考文献
Wang, Changsheng; Jung, Gun-Young; Batsanov, Andrei S.; Bryce, Martin R.; Petty, Michael C.
Journal of Materials Chemistry, 2002 , vol. 12, # 2 p. 173 - 180
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US5234946 A1, 1993 ;
反应条件
1: dimethyl pyridine-3,5-dicarboxylate With palladium 10 on activated carbon; hydrogen; trifluoroacetic acid in N,N-dimethyl acetamide
T=35 - 65°C; P=3750.38 - 5250.53 Torr; Autoclave;
2: With triethylamine
T=20 - 30°C; pH=9 - 10;
3: di-tert-butyl dicarbonate T=30 - 40°C;
参考文献
Kitayama, Masato
Patent: US2013/90337 A1, 2013 ;
Location in patent: Paragraph 0088; 0089 ;
参考文献
JÓNSSON, Erlendur; ARMAND, Michel Bernard; JOHANSSON, Jens Patrik
Patent: WO2013/72470 A1, 2013 ;
Location in patent: Page/Page column 6 ;
反应条件
in acetone; benzene
Ambient temperature2 weeks;
参考文献
Lavilla; Gotsens; Bosch
Synthesis, 1991 , # 10 p. 842 - 844
反应条件
1: 70 percent / sodium methoxide / toluene / 48 h / Ambient temperature
2: 69 percent / 2 N H2SO4 / 1.25 h / Heating
View Scheme
参考文献
Jokela, Reija; Tamminen, Tarja; Lounasmaa, Mauri
Heterocycles, 1985 , vol. 23, # 7 p. 1707 - 1722
