5-溴-3-碘-1H-吲唑合成路线 （共 5 条）
反应条件
potassium hydroxide; iodine in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
Crestey, Francois; Collot, Valerie; Stiebing, Silvia; Rault, Sylvain
Synthesis, 2006 , # 20 p. 3506 - 3514
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine in toluene T=70°C; P=750.075 Torr; Autoclave;
参考文献
Buchstaller, Hans-Peter; Wilkinson, Kai; Burek, Kasimir; Nisar, Yasmin
Synthesis, 2011 , # 19 art. no. T48411SS, p. 3089 - 3098
反应条件
1: With sodium hydride in tetrahydrofuran
T=0°C;
2: With trimethylsilyl ethoxymethyl chloride in tetrahydrofuran
T=0 - 20°C;
参考文献
Biogen Idec Ma Inc.
Patent: US2011/152260 A1, 2011 ;
Location in patent: Page/Page column 12-13 ;
反应条件
potassium hydroxide; tetrabutylammomium bromide in dichloromethane
T=0 - 20°C; 3 h;
参考文献
Crestey, Francois; Collot, Valerie; Stiebing, Silvia; Rault, Sylvain
Synthesis, 2006 , # 20 p. 3506 - 3514
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=25°C;
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; DAI, Xing; LIU, Hong; HE, Shuwen; DANG, Qung
Patent: WO2013/34048 A1, 2013 ;
Location in patent: Page/Page column 58 ;
