1-Boc-5-溴-3-碘-1H-吲唑合成路线 （共 3 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=25°C;
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; DAI, Xing; LIU, Hong; HE, Shuwen; DANG, Qung
Patent: WO2013/34048 A1, 2013 ;
Location in patent: Page/Page column 58 ;
反应条件
1: 5-bromo-1H-indazole With potassium hydroxide; iodine in N,N-dimethyl-formamide
2 h;
2: di-tert-butyl dicarbonate With 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; 0.333333 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2008/154241 A1, 2008 ;
Location in patent: Page/Page column 75 ;
反应条件
1: 67 percent / I2; KOH / dimethylformamide / 20 °C
2: DMAP; TEA / acetonitrile / 3 h
View Scheme
参考文献
Arnautu, Anca; Collot, Valerie; Ros, Javier Calvo; Alayrac, Carole; Witulski, Bernhard; Rault, Sylvain
Tetrahedron Letters, 2002 , vol. 43, # 15 p. 2695 - 2697
