(+/-)-3-苯基丁酸合成路线 （共 94 条）
反应条件
1: LiAlH4; diethyl ether
2: concentrated sulfuric acid; aqueous hydrobromic acid
View Scheme
参考文献
Hey et al.
Journal of the Chemical Society, 1953 , p. 2021,2023
反应条件
1: thionyl chloride / 2 h / |Reflux
2: AlCl3, aluminium chloride / toluene / 0 °C / |Reflux
3: sulfuric acid; potassium nitrate / sulfuric acid; ethyl acetate / 0 °C
4: hydrogenchloride; tin(ll) chloride / water / 0.5 h / 40 °C
View Scheme
参考文献
FUJITSU LIMITED; Kamiya, Nozomu; Tomonaga, Atsushi; Sugiyama, Hajime
Patent: US2013/317110 A1, 2013 ;
反应条件
1: (i) ClCO2Et, Et3N, (ii) NH3
2: LiAlH4 / diethyl ether / Heating
View Scheme
参考文献
Fort,A.W.; Leary,R.E.
Journal of the American Chemical Society, 1960 , vol. 82, p. 2494 - 2498
反应条件
1: SOCl2 / 0.5 h / Heating
2: 30 percent / chlorure d'acide / tetrachloroethene; hexane / 1) -10 deg C, 2 h; 2) room temp., 4 h
View Scheme
参考文献
Fkih-Tetouani, Souad; Daunis, Jacques; Jacquier, Robert; Viallefont, Philippe
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 113 - 120
