(+/-)-3-苯基丁酸合成路线 （共 94 条）
反应条件
(i) aq. KOH, EtOH, (ii) (decarboxylation); Multistep reaction;
参考文献
Kohler
American Chemical Journal, 1905 , vol. 34, p. 145
反应条件
iodine in acetic acid
参考文献
Moriwake,T.
Journal of Organic Chemistry, 1966 , vol. 31, p. 983 - 985
反应条件
aluminium trichloride
参考文献
Koelsch; Hochmann; Le Claire
Journal of the American Chemical Society, 1943 , vol. 65, p. 59
反应条件
1: 1.) Mg, 2.) cuprous bromide / 1.) ether 2: 10percent KOH / methanol / 8 h / Heating 3: 0.5 h / 190 °C View Scheme
参考文献
Kohler
American Chemical Journal, 1905 , vol. 34, p. 145
反应条件
(i) BF3, H2SO4, (ii) aq. H2SO4; Multistep reaction;
参考文献
Bott,K.
Chemische Berichte, 1967 , vol. 100, p. 2791 - 2797
反应条件
aluminium trichloride T=10°C;
参考文献
Suga,S. et al.
Tetrahedron Letters, 1969 , p. 3284 - 3286
反应条件
1: 70 percent / benzene / 6 h / Ambient temperature 2: 1.) LDA / 1.) THF, hexane, -78 deg C to RT, 3 h View Scheme
参考文献
Hertenstein, Ulrich; Huenig, Siegfried; Oeller, Manfred
Chemische Berichte, 1980 , vol. 113, # 12 p. 3783 - 3802
反应条件
1: 1.) Et3SiH, BF3-Et2O, 2.) H2 / 1.) methylene dichloride, 0 deg C, 1 h, 2.) Pd/C, RT, 45-50 psi, 20 h 2: 73 percent / aq. NaOH / methanol / 1 h / Heating View Scheme
参考文献
Smonou, Ioulia; Orfanopoulos, Michael
Synthetic Communications, 1990 , vol. 20, # 9 p. 1387 - 1397
反应条件
1: 100 percent / Zn, I2 / benzene; diethyl ether / 3 h / Heating 2: 1.) Et3SiH, BF3-Et2O, 2.) H2 / 1.) methylene dichloride, 0 deg C, 1 h, 2.) Pd/C, RT, 45-50 psi, 20 h 3: 73 percent / aq. NaOH / methanol / 1 h / Heating View Scheme
参考文献
Smonou, Ioulia; Orfanopoulos, Michael
Synthetic Communications, 1990 , vol. 20, # 9 p. 1387 - 1397
反应条件
1: NaOEt / ethanol 2: (i) aq. KOH, EtOH, (ii) (decarboxylation) View Scheme
参考文献
Kuchar; Brunova; Rejholec; et al.
Collection of Czechoslovak Chemical Communications, 1976 , vol. 41, # 2 p. 633 - 646
