(+/-)-3-苯基丁酸合成路线 （共 94 条）
参考文献
Consiglio,G.; Pino,P.
Helvetica Chimica Acta, 1976 , vol. 59, # 65 p. 642 - 645
反应条件
hydrogenchloride in tetrahydrofuran 5 h; Ambient temperature; Yield given;
参考文献
Hertenstein, Ulrich; Huenig, Siegfried; Oeller, Manfred
Chemische Berichte, 1980 , vol. 113, # 12 p. 3783 - 3802
反应条件
1: LDA / tetrahydrofuran / 1) -78 deg C, 2) to r.t., overnight 2: 2 N HCl / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Hertenstein, Ulrich; Huenig, Siegfried; Oeller, Manfred
Chemische Berichte, 1980 , vol. 113, # 12 p. 3783 - 3802
反应条件
1: LDA 2: 2 N HCl / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Hertenstein, Ulrich; Huenig, Siegfried; Oeller, Manfred
Chemische Berichte, 1980 , vol. 113, # 12 p. 3783 - 3802
反应条件
1: 95 percent / piperidine, glacial acetic acid / ethanol / 8 h / Heating 2: 1.) Mg, 2.) cuprous bromide / 1.) ether 3: 10percent KOH / methanol / 8 h / Heating 4: 0.5 h / 190 °C View Scheme
参考文献
Patra; Kumar Misra
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 1 p. 66 - 69
反应条件
oxonium; (S)-1-(diphenylphosphinomethyl)-2-methyl-propylamine; nickel dichloride 1.) ether, 0 deg C; Yield given. Multistep reaction;
参考文献
Hayashi, Tamio; Kanehira, Koichi; Hioki, Tsuyoshi; Kumada, Makoto
Tetrahedron Letters, 1981 , vol. 22, p. 137 - 140
反应条件
in tetrahydrofuran 1.) -30 deg C, 1 h, 2.) 0 deg C, 1 h;
参考文献
Fujisawa, Tamotsu; Sato, Toshio; Kawara, Tatsuo; Kawashima, Masatoshi
Tetrahedron Letters, 1980 , vol. 21, p. 2181 - 2184
参考文献
Ahlbrecht,H.; Vonderheid,C.
Synthesis, 1975 , p. 512 - 515
反应条件
1: 1.) n-BuLi / 1.) THF, cyclohexane, -78 deg C, 1 h, 2.) THF, cyclohexane, a) -78 deg C, 1 h, b) from -78 deg C to RT, overnight 2: 1.) ZnBr2, 2.) aq. HCl / 1.) 1,4-dioxane, reflux, 1 h, 2.) 1,4-dioxane, reflux, 4 h View Scheme
参考文献
Katritzky, Alan R.; Toader, Dorin; Xie, Linghong
Synthesis, 1996 , # 12 p. 1425 - 1427
反应条件
1: (i) LDA, THF, hexane, (ii) /BRN= 969135/ 2: aq. HCl View Scheme
参考文献
Ahlbrecht,H.; Vonderheid,C.
Synthesis, 1975 , p. 512 - 515
