(+/-)-3-苯基丁酸合成路线 （共 94 条）
参考文献
Tiffeneau
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1904 , vol. 138, p. 987
Annales de Chimie (Cachan, France), 1907 , vol. <8> 10, p. 173
参考文献
v. Braun; Grabowski; Kirschbaum
Chemische Berichte, 1913 , vol. 46, p. 1280
反应条件
Tb(OTf)3 in chlorobenzene T=250°C; Friedel-Crafts reaction; 4 h;
参考文献
Cui, Dong-Mei; Zhang, Chen; Kawamura, Masato; Shimada, Shigeru
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1741 - 1745
反应条件
trifluoromethylsulfonic anhydride; triphenyl-phosphine oxide in 1,2-dichloro-ethane T=25°C; 4 h;
参考文献
Journal of Organic Chemistry, , vol. 54, # 5 p. 1144 - 1149
参考文献
Pfeiffer; Jenning; Stoecker
Justus Liebigs Annalen der Chemie, 1949 , vol. 563, p. 73,85
参考文献
Speight; Stevenson; Thorpe
Journal of the Chemical Society, 1924 , vol. 125, p. 2191
参考文献
Varadharaj, Govindarajulu; Hazell, Keith; Reeve, Christopher D.
Tetrahedron Asymmetry, 1998 , vol. 9, # 7 p. 1191 - 1195
反应条件
sodium hydroxide; sodium phosphate buffer; sulfuric acid 1.) toluene, reflux, 2.) 40 deg C, 3 h, pH 7.5, lipase B from Candida antarctica presence; Yield givenMultistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yang, Hong; Henke, Erik; Bornscheuer, Uwe T.
Journal of Organic Chemistry, 1999 , vol. 64, # 2-5 p. 1709 - 1712
反应条件
1: sulfuric acid / Reflux 2: Pseudomonas cepacia P2 hydrolase; water / 65 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction View Scheme
参考文献
Deasy, Rebecca E.; Brossat, Maude; Moody, Thomas S.; Maguire, Anita R.
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 47 - 61
反应条件
1: sulfuric acid / Reflux 2: porcine pancrease grade II; water / 65 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction View Scheme
参考文献
Deasy, Rebecca E.; Brossat, Maude; Moody, Thomas S.; Maguire, Anita R.
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 47 - 61
