(+/-)-3-苯基丁酸合成路线 （共 94 条）
反应条件
in diethyl ether
T=0 - 20°C; 4.16667 h;
参考文献
SEPRACOR INC.
Patent: US2005/143443 A1, 2005 ;
Location in patent: Page/Page column 26-27 ;
反应条件
1: 1.) phosphorus pentachloride; 2.) aluminum chloride / 1.) benzene, reflux, 0.5 h; 2.) reflux, 20 min
2: 94 percent / lithium aluminum hydride
3: 35 percent / potassium hydrogen sulfate / Heating
View Scheme
参考文献
Noland, Wayland E.; Kameswaran, Venkataraman; Landucci, Lawrence L.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4564 - 4572
参考文献
Fernandez-Alvaro, Elena; Snajdrova, Radka; Jochens, Helge; Davids, Timo; Boettcher, Dominique; Bornscheuer, Uwe T.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 37 p. 8584 - 8587
参考文献
Levene; Marker
Journal of Biological Chemistry, 1931 , vol. 93, p. 749,762
Journal of Biological Chemistry, 1935 , vol. 110, p. 329,338
Show Details
Stewart; Lipkin
Journal of the American Chemical Society, 1939 , vol. 61, p. 3297 Anm. 2
反应条件
sodium hydroxide; sodium phosphate buffer; sulfuric acid
1.) toluene, reflux, 2.) 40 deg C, 3 h, pH 7.5, lipase B from Candida antarctica presence; Yield givenMultistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yang, Hong; Henke, Erik; Bornscheuer, Uwe T.
Journal of Organic Chemistry, 1999 , vol. 64, # 2-5 p. 1709 - 1712
参考文献
Levene; Marker
Journal of Biological Chemistry, 1933 , vol. 100, p. 685,688
反应条件
1: sulfuric acid / Reflux
2: Pseudomonas cepacia P2 hydrolase; water / 65 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction
View Scheme
参考文献
Deasy, Rebecca E.; Brossat, Maude; Moody, Thomas S.; Maguire, Anita R.
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 47 - 61
反应条件
1: sulfuric acid / Reflux
2: Pseudomonas stutzeri hydrolase; water / 65 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction
View Scheme
参考文献
Deasy, Rebecca E.; Brossat, Maude; Moody, Thomas S.; Maguire, Anita R.
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 47 - 61
参考文献
Weidler; Bergson
Acta Chemica Scandinavica (1947-1973), 1964 , vol. 18, p. 1483,1485
反应条件
1: LiAlH4
2: (i) Ac2O, Py, (heating), (ii) (pyrolysis)
View Scheme
参考文献
Fort,A.W.; Leary,R.E.
Journal of the American Chemical Society, 1960 , vol. 82, p. 2494 - 2498
