5-甲基-6(5H)-菲啶酮合成路线 （共 78 条）
反应条件
1.1: acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere
2.1: sodium cyanoborohydride / methanol / 16 h / 0 - 20 °C / Inert atmosphere
3.1: acetic acid / water; acetonitrile / 0.5 h / 20 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: pyridine; 1,10-phenanthroline; potassium tert-butylate / 0.18 h / 20 - 160 °C / Inert atmosphere; Microwave irradiation
5.1: BaMnO4 / dichloromethane / 12 h / 45 °C / Inert atmosphere
View Scheme
参考文献
Roman, Daniela Sustac; Takahashi, Yoko; Charette, Andre B.
Organic Letters, 2011 , vol. 13, # 12 p. 3242 - 3245
反应条件
2,2'-azo-bisisobutyronitrile; diphenyl diselenide; tri-n-butyl-tin hydride in benzene
1 h; Heatingother reagent: Bu3SnH/azobis(isobutyronitrile);
参考文献
Crich, David; Hwang, Jae-Taeg
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2765 - 2770
反应条件
1: 10percent aq. NaOH
2: 15 percent / Bu3SnH, AIBN / toluene / 24 h / Heating
View Scheme
参考文献
Bowman, W. Russell; Heaney, Harry; Jordan, Benjamin M.
Tetrahedron, 1991 , vol. 47, # 48 p. 10119 - 10128
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-20°C; 1 h;
参考文献
Rousseau, Geraldine; Robert, Frederic; Landais, Yannick
Chemistry - A European Journal, 2009 , vol. 15, # 42 p. 11160 - 11173
反应条件
1: thionyl chloride / 5 h / Reflux
2: triethylamine / dichloromethane / 1 h / 20 °C
3: di-μ-chlorobis [5-hydroxy-2-[1-(hydroxyimino)ethyl]phenyl]palladium(II) dimer; potassium carbonate / N,N-dimethyl acetamide / 72 h / 140 °C / Inert atmosphere
View Scheme
参考文献
Zhang, Guofu; Zhao, Xiaobao; Yan, Yunbing; Ding, Chengrong
European Journal of Organic Chemistry, 2012 , # 4 p. 669 - 672
反应条件
potassium carbonate in acetone
20 h; Heating;
参考文献
Majumdar; Chattopadhyay; Gupta
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 12 p. 1138 - 1140
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene
Reflux;
参考文献
Rousseau, Geraldine; Robert, Frederic; Landais, Yannick
Chemistry - A European Journal, 2009 , vol. 15, # 42 p. 11160 - 11173
反应条件
1: 1'-methylspiro[cyclohexa[2,5]diene-1,3'-indolin]-2'-one With lithium diisopropyl amide in tetrahydrofuran
T=-40°C; 1 h;
2: methyl iodide in tetrahydrofuran
参考文献
Rousseau, Geraldine; Robert, Frederic; Landais, Yannick
Chemistry - A European Journal, 2009 , vol. 15, # 42 p. 11160 - 11173
反应条件
1: thionyl chloride / 5 h / Reflux
2: triethylamine / dichloromethane / 1 h / 20 °C
3: di-μ-chlorobis [5-hydroxy-2-[1-(hydroxyimino)ethyl]phenyl]palladium(II) dimer; potassium carbonate / N,N-dimethyl acetamide / 24 h / 140 °C / Inert atmosphere
View Scheme
参考文献
Zhang, Guofu; Zhao, Xiaobao; Yan, Yunbing; Ding, Chengrong
European Journal of Organic Chemistry, 2012 , # 4 p. 669 - 672
反应条件
1: triethylamine / dichloromethane / 1 h / 20 °C
2: di-μ-chlorobis [5-hydroxy-2-[1-(hydroxyimino)ethyl]phenyl]palladium(II) dimer; potassium carbonate / N,N-dimethyl acetamide / 72 h / 140 °C / Inert atmosphere
View Scheme
参考文献
Zhang, Guofu; Zhao, Xiaobao; Yan, Yunbing; Ding, Chengrong
European Journal of Organic Chemistry, 2012 , # 4 p. 669 - 672
