5-甲基-6(5H)-菲啶酮合成路线 （共 78 条）
反应条件
1: thionyl chloride / 5 h / Reflux
2: triethylamine / dichloromethane / 1 h / 20 °C
3: di-μ-chlorobis [5-hydroxy-2-[1-(hydroxyimino)ethyl]phenyl]palladium(II) dimer; potassium carbonate / N,N-dimethyl acetamide / 72 h / 140 °C / Inert atmosphere
View Scheme
参考文献
Zhang, Guofu; Zhao, Xiaobao; Yan, Yunbing; Ding, Chengrong
European Journal of Organic Chemistry, 2012 , # 4 p. 669 - 672
反应条件
1: 98 percent / 10percent sodium hydroxide / 2 h
2: 50 percent / palladium(II) acetate, sodium carbonate / N,N-dimethyl-acetamide / 24 h / 160 °C
View Scheme
参考文献
Ames, D.E.; Opalko, A.
Tetrahedron, 1984 , vol. 40, # 10 p. 1919 - 1926
反应条件
2: 10percent aq. NaOH
3: 15 percent / Bu3SnH, AIBN / toluene / 24 h / Heating
View Scheme
参考文献
Bowman, W. Russell; Heaney, Harry; Jordan, Benjamin M.
Tetrahedron, 1991 , vol. 47, # 48 p. 10119 - 10128
反应条件
1: With sulfuric acid; sodium nitrite
T=0 - 5°C; 0.25 h;
2: With CuSO4‵5H2O; sodium chloride; ascorbic acid powder
T=0 - 20°C; 1 h;
参考文献
Maggio, Benedetta; Fontana, Gianfranco; Raffa, Demetrio; Ferrante, Francesco; Daidone, Giuseppe
Heterocycles, 2014 , vol. 89, # 1 p. 83 - 101
反应条件
T=600°C; P=0.01 Torr;
参考文献
Lister, Troy; Prager, Rolf H.; Tsaconas, Michael; Wilkinson, Kerry L.
Australian Journal of Chemistry, 2003 , vol. 56, # 9 p. 913 - 916
反应条件
sodium tetrahydroborate in methanol; diethyl ether
T=5 - 10°C; Irradiation;
参考文献
Naito, Takeaki; Ninomiya, Ichiya
Heterocycles, 1984 , vol. 22, # 8 p. 1705 - 1708
反应条件
sodium hydroxide in ethylene glycol
10 h; Heating;
参考文献
Mikhailovskii, A. G.; Shklyaev, V. S..
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 4 p. 445 - 448
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 4 p. 531 - 534
反应条件
sodium hydroxide; methyl iodide
1.5 h; by sonochemical activation;
参考文献
Diaba, Faiza; Lewis, Ifan; Grignon-Dubois, Micheline; Navarre, Sebastien
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4830 - 4832
反应条件
1: 83 percent / benzene / 2 h / Heating
2: 0.2 g / 20percent NaOH / ethane-1,2-diol / 10 h / Heating
View Scheme
参考文献
Mikhailovskii, A. G.; Shklyaev, V. S..
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 4 p. 445 - 448
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 4 p. 531 - 534
反应条件
1: 70 percent / potassium hydroxide / methanol / Heating
2: 22 percent / acetic acid / Ambient temperature; Irradiation
View Scheme
参考文献
Ninomiya, Ichiya; Kiguchi, Toshiko; Yamauchi, Sadami; Naito, Takeaki
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 197 - 202
