3-异丙基[1,2,4]三唑并[4,3-a]吡啶-6-甲醛合成路线 （共 4 条）
反应条件
1: 6-bromo-3-isopropyl[1,2,4]triazolo[4,3-a]pyridine hydrochloride With isopropylmagnesium chloride in tetrahydrofuran; diethyl ether
T=0°C; 1 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; diethyl ether
T=0°C; 0.166667 h;
参考文献
PHARMACIA and UPJOHN COMPANY LLC
Patent: WO2006/18727 A2, 2006 ;
Location in patent: Page/Page column 57-58 ;
WO 2006/018727 A2
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran
T=-8 - 0°C; 1.41667 h;
2: in DMF (N,N-dimethyl-formamide)
T=55°C; 2.08333 h;
参考文献
Pfizer Inc
Patent: US2004/143119 A1, 2004 ;
Location in patent: Page 8 ;
US 20040143119 A1
反应条件
isopropylmagnesium chloride in tetrahydrofuran
T=-8 - 55°C; 3.5 h; Cooling with acetone-dry ice;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/20438 A2, 2004 ;
Location in patent: Page 46-47 ;
WO 2004/020438 A2
反应条件
in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
Pfizer Inc.
Patent: US2003/96838 A1, 2003 ;
