反应条件
1: 1-bromo-4-fluorobenzene With magnesium in 2-Me-THF RefluxInert atmosphere; 2: thien-2-yl bromide With Cl2Ni(1,2-bis(diphenylphosphino)ethane) in 2-Me-THF T=2 - 22°C; Inert atmosphere; 3: With acetic acid in 2-Me-THF; water 0.25 h; Inert atmosphere;
参考文献
Fillers, Walter Ferdinand Maria; Broeckx, Rudy Laurent Maria; Nieste, Patrick Hubert J.; Hatsuda, Masanori; Yoshinaga, Masahiko; Yada, Mitsuhiro
Patent: US2010/99883 A1, 2010 ;
Location in patent: Page/Page column 40 ;
US 20100099883 A1