1: acrylic acid With potassium tert-butylate in water T=20°C; 0.166667 h; Inert atmosphere; 2: 1-bromo-4-fluorobenzene With C16H21Br2N3Pd in water T=120°C; Mizoroki-Heck reaction; 24 h; Inert atmosphereSealed tube;
n-butyllithium in tetrahydrofuran; hexane T=-78°C; Inert atmosphere;
参考文献
Acker, Timothy M.; Khatri, Alpa; Vance, Katie M.; Slabber, Cathryn; Bacsa, John; Snyder, James P.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6434 - 6456