1: 1-bromo-4-fluorobenzene With iodine; magnesium in tetrahydrofuran 2: 5-cyano-isobenzofuran-1-one in tetrahydrofuran; dichloromethane T=-4 - -2°C; 3: 3-(N,N-dimethylamino)-propylmagnesium chloride With ammonium chloride more than 3 stages;
thien-2-yl(cyano)copper lithium; naphthalenyllithium multistep reaction; other functionalized organic halides; other acid chloride; cross coupling reaction of organocopper reagents with acid chlorides to form ketones;
参考文献
Rieke, Reuben D.; Klein, Walter R.; Wu, Tse-Chong
Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2492 - 2500
