反应条件
1: 1.) n-BuLi / 1.) n-hexane, diethyl ether, -50 deg C, 40 min, 2.) n-hexane, diethyl ether, from -50 deg C to -10 deg C
2: 96 percent / trifluoroacetic acid / 1.5 h / Heating
3: 93 percent / 1,1,1-trichloro-ethane / 3 h / Heating
4: 93 percent / Zn (powder), acetic acid / H2O / 45 °C
View Scheme
参考文献
Perregaard; Moltzen; Meier; Sanchez
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1998 - 2008
