(1R,2R)-1,2-环己烷二甲酸合成路线 （共 17 条）
反应条件
1: in ethanol T=35 - 75°C; 30 h; 2: With hydrogenchloride in water; ethyl acetate 1 h;
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shri Prakash Dhar; SINGH, Ramesh Chandra; CHAVDA, Rajendra Gokalbhai
Patent: WO2013/121440 A1, 2013 ;
Location in patent: Page/Page column 26; 27 ;
反应条件
acetic acid; sodium nitrite in dimethyl sulfoxide T=40°C; 8 h; Inert atmosphere;
参考文献
Malihi, Farzad; Clive, Derrick L. J.; Chang, Che-Chien; Minaruzzaman
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 996 - 1013
反应条件
1: ethanol / 6.5 h / -70 - 20 °C / Resolution of racemate 2: hydrogenchloride / water View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh, Babu; GAHLOT, Udaibhan, Singh; SINGH, Tarun, Kumar; KHANDURI, Chandra, Has
Patent: WO2012/131606 A1, 2012 ;
反应条件
1.1: palladium; hydrogen / methanol / 30 - 35 °C 2.1: ethanol / 30 h / 35 - 75 °C 2.2: 1 h View Scheme
参考文献
LEE PHARMA LIMITED; ALLA, Venkat Reddy; ALLA, Raghu Mitra; DUBEY, Ajay Kumar; REDDY, P., Ramakrishna
Patent: WO2014/102808 A1, 2014 ;
反应条件
FS-Hydrodex β-6TBDM column Resolution of racemate;
参考文献
Mueller, Christian E.; Zell, Daniela; Hrdina, Radim; Wende, Raffael C.; Wanka, Lukas; Schuler, Soeren M. M.; Schreiner, Peter R.
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8465 - 8484
反应条件
1.1: acetyl chloride / Heating 1.2: NH3 gas / CH2Cl2 / 20 °C 1.3: 74 percent / phenyliodine(III) trifluoroacetate / acetonitrile; H2O / 20 °C 2.1: 81 percent / sodium hydroxide / tetrahydrofuran; H2O View Scheme
参考文献
Berkessel, Albrecht; Glaubitz, Katja; Lex, Johann
European Journal of Organic Chemistry, 2002 , # 17 p. 2948 - 2952
参考文献
Berkessel, Albrecht; Glaubitz, Katja; Lex, Johann
European Journal of Organic Chemistry, 2002 , # 17 p. 2948 - 2952
参考文献
Berkessel, Albrecht; Glaubitz, Katja; Lex, Johann
European Journal of Organic Chemistry, 2002 , # 17 p. 2948 - 2952
反应条件
1: diethyl ether 2: LiAlH4 / diethyl ether View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shri Prakash Dhar; SINGH, Ramesh Chandra; CHAVDA, Rajendra Gokalbhai
Patent: WO2013/121440 A1, 2013 ;
Location in patent: Page/Page column 27 ;
反应条件
sulfuric acid T=40°C; 18 h;
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh, Babu; GAHLOT, Udaibhan, Singh; SINGH, Tarun, Kumar; KHANDURI, Chandra, Has
Patent: WO2012/131606 A1, 2012 ;
Location in patent: Page/Page column 13 ;
