2-(2-甲氧基-5-甲基苯基)乙胺合成路线 （共 4 条）
反应条件
ammonium hydroxide; nickel in ethanol
T=40 - 50°C; 48 h;
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 20 h / Heating
2: 69 percent / thionyl chloride, pyridine / toluene / 24 h / Ambient temperature
3: 91 percent / KI / dimethylsulfoxide / 20 h / Ambient temperature
4: aq. NH3, Raney Ni / ethanol / 48 h / 40 - 50 °C
View Scheme
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
1: 69 percent / thionyl chloride, pyridine / toluene / 24 h / Ambient temperature
2: 91 percent / KI / dimethylsulfoxide / 20 h / Ambient temperature
3: aq. NH3, Raney Ni / ethanol / 48 h / 40 - 50 °C
View Scheme
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
1: 91 percent / KI / dimethylsulfoxide / 20 h / Ambient temperature
2: aq. NH3, Raney Ni / ethanol / 48 h / 40 - 50 °C
View Scheme
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
