(R)-2,3-二氢-1,4-苯并二恶烷-2-甲胺合成路线 （共 14 条）
反应条件
chiral stationary phase including (R)-naphthylethyl-carbamate-functionalized CF6 in ethanol; n-heptane; trifluoroacetic acid
T=20°C; Purification / work up;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; ARMSTRONG, Daniel, W.; PING, Sun; BREITBACH, Zachary, S.; WANG, Chunlei
Patent: WO2010/148191 A2, 2010 ;
Location in patent: Page/Page column 45-49; 64 ;
反应条件
hydrazine hydrate; Trimethylene glycol in methanol
2 h; Heating;
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: K2CO3 / acetone / 5 h / Heating
2: NaN3 / dimethylformamide / 3 h / 90 °C
3: hydrazine hydrate / PdO / methanol / 2 h / Heating
View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: HCl / H2O / 5 h / 75 °C
2: TEA / CH2Cl2 / 2 h / 20 °C
3: H2 / Pd/C / ethyl acetate; methanol / 3 h / 20 °C
4: K2CO3 / acetone / 5 h / Heating
5: NaN3 / dimethylformamide / 3 h / 90 °C
6: hydrazine hydrate / PdO / methanol / 2 h / Heating
View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: H2 / Pd/C / ethyl acetate; methanol / 3 h / 20 °C
2: K2CO3 / acetone / 5 h / Heating
3: NaN3 / dimethylformamide / 3 h / 90 °C
4: hydrazine hydrate / PdO / methanol / 2 h / Heating
View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: KOH / ethanol / 24 h / Heating
2: HCl / H2O / 5 h / 75 °C
3: TEA / CH2Cl2 / 2 h / 20 °C
4: H2 / Pd/C / ethyl acetate; methanol / 3 h / 20 °C
5: K2CO3 / acetone / 5 h / Heating
6: NaN3 / dimethylformamide / 3 h / 90 °C
7: hydrazine hydrate / PdO / methanol / 2 h / Heating
View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: TEA / CH2Cl2 / 2 h / 20 °C
2: H2 / Pd/C / ethyl acetate; methanol / 3 h / 20 °C
3: K2CO3 / acetone / 5 h / Heating
4: NaN3 / dimethylformamide / 3 h / 90 °C
5: hydrazine hydrate / PdO / methanol / 2 h / Heating
View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: NaN3 / dimethylformamide / 3 h / 90 °C
2: hydrazine hydrate / PdO / methanol / 2 h / Heating
View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: H2 / Pd/C
2: pyridine / 0 °C
3: dimethylformamide / Heating
4: NH2-NH2*H2O / 2-methoxy-ethanol / Heating
View Scheme
参考文献
Ferri; Pallavicini; Piccini; Valoti; Villa
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 12 SUPPL. p. 1153 - 1163
反应条件
1: pyridine / 0 °C
2: H2 / Pd/C
3: H2 / Pd/C
4: pyridine / 0 °C
5: dimethylformamide / Heating
6: NH2-NH2*H2O / 2-methoxy-ethanol / Heating
View Scheme
参考文献
Ferri; Pallavicini; Piccini; Valoti; Villa
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 12 SUPPL. p. 1153 - 1163
